The 3D-e-Chem team showcased the different structural cheminformatics tools during the 4th National eScience symposium in Amsterdam on 17 October 2016. The 3D-e-Chem demos included a video demonstration of the 3D-e-Chem Virtual Machine (YouTube, Stefan Verhoeven), KNIME workflows using the 3D-e-Chem KNIME nodes prepared (YouTube, Ross McGuire), a 3D-e-Chem-VM poster (doi:10.5281/zenodo.161567, Márton Vass), and a Virtual Reality demonstration of linked to the KLIFS database (YouTube, Albert Kooistra).